Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Human PDA Cell Lines: single cell RNA-Sequencing in nomral versus serum-free media

ABSTRACT: Six Human PDA Cell Lines (KP4, Miapaca2, Panc1, Patu8902, PK45H, SW1990) were cultured in both normal and serum-free media conditions and then were subjected to Single-Cell RNA Sequqncing.

ORGANISM(S): Homo sapiens

PROVIDER: GSE266034 | GEO | 2026/01/16

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Human PDA Cell Lines: single cell RNA-Sequencing after treatment with Trametinib (TRAM) and/or Hydroxychloroquine (HCQ)

Project description:Several Human PDA Cell Lines (ASPC1, PANC1, KP4, HPAFII, PATU8988S, PK45H, S2013, CAPAN1, BXPC3, HPAC, SW1990, MIAPACA2) were cultured and treated with DMSO, Trametinib (TRAM), Hydroxychloroquine (HCQ) and the combination of them before being prepared for Single-Cell RNA Sequencing

2026-01-16 | GSE310584 | GEO

Single-Cell Barcoded Lineage Tracing in KP4 PDA Cell Line

Project description:The KP4 PDA cell line was used to experimentally assess cross-lineage plasticiyty between different states of Pancreatic Malignant Cells

2026-01-16 | GSE268229 | GEO

TF overexpression assay in PDA cell lines (Bulk RNA-Seq)

Project description:In this study the top Lineage Master Regulators of PDA were overexpressed in the KP4 Morphogenic cell line to study their reprogramming effect

2026-01-16 | GSE161368 | GEO

In Vivo pooled CRISPRko screens in PDA Cell Lines

Project description:We tested the essentiality of PDA state-specific Master Regulators in vivo by transducing a sgRNA library targeting 93 regulatory proteins into Cas9 expressing KP4 and HPAFII human cell lines. Cells were then injected into immunocompromised mice for genomic sequencing.

2026-01-16 | GSE270853 | GEO

Single-Cell Barcoded Lineage Tracing using KP4 PDA Cell Line - Pre and Post Drug Treatment with Trametinib

Project description:The KP4 PDA cell line (Untreated, DMSO-Treated and Trametinib-Treated) was used to experimentally assess plasticity between MAPK-Positive and MAPK-Negative states of Pancreatic Malignant Cells

2026-01-16 | GSE292402 | GEO

In vitro drug screening of RAF/MEK/ERK Inhibitors in two PDA Cell Lines

Project description:In this study 14 different RAF, MEK, or ERK inhibitors were tested in ASPC1 and PANC1 PDA cell lines

2024-04-28 | GSE252002 | GEO

The immunological comparison of control PDA tumors and Krt19-edited PDA tumors

Project description:Our studies indicate that cancer cells of carcinomas are coated with CXCL12 chemokine in covalent conjugation with keratin-19 (KRT19). Murine pancreatic ductal adenocarcinomas (PDA) formed with Krt19-edited cancer cells lack the CXCL12-coating and are infiltrated with T cells, compared to tumors formed with control sgScramble PDA cells. To probe the immunological role of this CXCL12-coating thoroughly, bulk RNA sequencing of subcutaneous (s/c) murine sgScramble PDA tumors and Krt19-edited PDA tumors were conducted. As comparison, an immunogenic tumor model was also assessed. To do so, s/c sgScramble PDA tumors and PDA tumors formed with sgScramble cells exppressing doxcycline-inducible ovalbumin (icOVA) were harvested and processed for bulk RNA sequencing.

2022-01-04 | GSE192853 | GEO

The immunological comparison of control PDA tumors and Krt19-edited PDA tumors

2022-01-07 | GSE193027 | GEO

Black Seed Derivative Thymoquinone (TQ) Suppresses Pancreatic Ductal Adenocarcinoma Associated Oncogenic circRNAs

Project description:To reveal the molecular mechanisms underlying TQ tratment on cell proliferation, we performed circRNA-seq analysis on human PDAC cell cultures (MiaPaCa2 and Panc1 cells).

2025-09-09 | GSE307438 | GEO

Coordinated transcriptional and catabolic programs support iron dependent adaptation to RAS-MAPK pathway inhibition in pancreatic cancer [RNA-Seq]

Project description:In this study, human pancreatic ductal adenocarcinoma cells lines (KP4, MiaPaca2) were treated with the MEK inhibitor, Trametinib or DMSO for 48hrs prior to RNA-seq profiling to evaluate significant gene expression changes associated with MEK inhibition. To assess the role of transcription factors MYC and TFE3 in regulation of gene expression changes associated with MEK inhibition, we performed chromatin immunoprecipitation using antibodies against c-MYC and TFE3 in KP4 cells following 48hrs of Trametinib or DMSO treatment.

2022-07-06 | GSE206267 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data