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PVRL Is A Receptor For Measles Virus

ABSTRACT: Measles virus infects serum activated airway epithelial cells and many adenocarcinoma cell lines. A microarray analysis was performed on virus permissive versus non-permissive cells. Membrane protein genes that were upregulated in permissive cells were tested as receptor/entry factors. Membrane protein genes that were upregulated in smooth airway epithelial cells (SAEC) following growth in 10% fetal calf serum that made the cell line permissive to measles virus were identified. Membrane protein genes that were upregulated in adenocarcinoma cells that were permissive to wild type measles virus infection were identified.

ORGANISM(S): Homo sapiens

PROVIDER: GSE26636 | GEO | 2011/07/29

SECONDARY ACCESSION(S): PRJNA136459

REPOSITORIES: GEO

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PVRL Is A Receptor For Measles Virus

Project description:Measles virus infects serum activated airway epithelial cells and many adenocarcinoma cell lines. A microarray analysis was performed on virus permissive versus non-permissive cells. Membrane protein genes that were upregulated in permissive cells were tested as receptor/entry factors. Membrane protein genes that were upregulated in smooth airway epithelial cells (SAEC) following growth in 10% fetal calf serum that made the cell line permissive to measles virus were identified. Membrane protein genes that were upregulated in adenocarcinoma cells that were permissive to wild type measles virus infection were identified. [SAEC]: Airway cells (SAEC) grown in serum free media (SAGM) were purchaced from Lonza. Half the cells were cultured in SAGM, the other half were transferred into Dulbecco's 10% fetal calf serum for 24 hrs. RNA was harvested from the cells by the Qiagen RNAeasy [Adenocarcinoma cells]: MCF7, MDA-MB-468, T47D, NCI-H358, NCI-H125, MGH24 cells were permissive and A549 and MDA-MB-231 cells were non-permissive.

2011-07-28 | E-GEOD-26636 | biostudies-arrayexpress

Time course of measles infection in healthy human airway epithelial cell cultures

Project description:The goal of this study was to examine changes in gene expression over time in healthy human airway epithelia infected with measles virus.

2023-08-04 | GSE229685 | GEO

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Project description:The goal of this study was to compare cell composition, gene expression, and infectivity of different cell types in human airway epithelia following exposure to measles virus. Samples included control epithelia exposed to a mock infection and measles-virus-exposed epithelia that were sorted according to detection of green fluorescent protein (GFP) prior to library preparation and sequencing.

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Project description:Measles (MV) is an aerosol-transmitted virus that affects more than 10 million children each year and accounts for approximately 120,000 deaths. While it was long believed to replicate in the respiratory epithelium before disseminating, it was recently shown to initially infect macrophages and dendritic cells of the airways using the signaling lymphocytic activation molecule (SLAM, CD150) as receptor. These cells then cross the respiratory epithelium and ferry the infection to lymphatic organs where MV replicates vigorously. How and where the virus crosses back into the airways has remained unknown. However, certain carcinoma cell lines have been described to be either permissive for wt MV infection, or not (Leonard VHJ et al. 2008). Therefor, we decided to compare the expression pattern of permissive and non-permissive cell lines by micro array analysis. Based on functional analyses of surface proteins preferentially expressed on virus-permissive epithelial cell lines, we identified nectin-4 (poliovirus-receptor-like-4) as a candidate receptor. The dataset comprises 21 samples divided into seven sample groups each representing 3 biological replicates of one out of 7 cell lines.

2011-11-02 | E-GEOD-32155 | biostudies-arrayexpress

Measles morbillivirus

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Identification of the epithelial receptor for measles virus

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Mutational analysis of measles virus suggests constraints on antigenic variation of the glycoproteins

Project description:RNAseq of mutant measles virus libraries Insertional mutagenesis of measles to identify tolerated locations Mutant measles virus libraries were constructed as described in: Heaton, N.S., Sachs, D., Chen,C.J., Hai, R., and Palese, P. (2013). Genome-wide mutagenesis of influenza virus reveals unique plasticity of the hemagglutinin and NS1 proteins. PNAS. 110, 20248-20253.

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Editing of measles virus genomic RNA by ADAR1

Project description:RNAseq analysis of purified measles virus RNA grown in standard HeLa cells, p150KO or ADAR1KO cells

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Mutational analysis of measles virus suggests constraints on antigenic variation of the glycoproteins

Project description:RNAseq of mutant measles virus libraries

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Cyclical quasispecies re-equilibration of dual-tropic measles virus

Project description:RNAseq analysis of purified measles virus ribonucleocapsids after adaptation to lymphocytes (Granta-519) or epithelial cells (H358)

2019-02-06 | GSE126126 | GEO

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