Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Integrated multi-omic analysis of GATA2 and GATA3 unveil their master regulatory roles on the trophoblast fate [CUT&Tag]

ABSTRACT: The commitment and differentiation of human placental progenitor cells are crucial for a successful pregnancy, but the underlying regulatory mechanism remains poorly understood. Here we identified the transcription factor (TF), GATA2 and GATA3, exerting genetic redundancy, for cell fate decision of trophoblast cells. Mechanistically, GATA2&3 maintain stemness of TSC by occupying open chromatin regions, mediating promoter activity, enhancer activity.

ORGANISM(S): Homo sapiens

PROVIDER: GSE266533 | GEO | 2026/09/01

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Integrated multi-omic analysis of GATA2 and GATA3 unveil their master regulatory roles on the trophoblast fate [HiCUT]

Project description:The commitment and differentiation of human placental progenitor cells are crucial for a successful pregnancy, but the underlying regulatory mechanism remains poorly understood. Here we identified the transcription factor (TF), GATA2 and GATA3, exerting genetic redundancy, for cell fate decision of trophoblast cells. Mechanistically, GATA2&3 maintain stemness of TSC by occupying open chromatin regions, mediating promoter activity, enhancer activity.

2026-09-01 | GSE278381 | GEO

Integrated multi-omic analysis of GATA2 and GATA3 unveil their master regulatory roles on the trophoblast fate [scRNA-seq]

Project description:The commitment and differentiation of human placental progenitor cells are crucial for a successful pregnancy, but the underlying regulatory mechanism remains poorly understood. Here we identified the transcription factor (TF), GATA2 and GATA3, exerting genetic redundancy, for cell fate decision of trophoblast cells. At stage of EPSC, inducible overexpression GATA2&3 reprogrammed hEPSCs to trophoblast lineage. During differentiation of TSCM, double knockout GATA2&3 failed for initiation trophoblast cell fate.

2026-09-01 | GSE266536 | GEO

Integrated multi-omic analysis of GATA2 and GATA3 unveil their master regulatory roles on the trophoblast fate [ATAC-seq]

2026-09-01 | GSE266532 | GEO

Integrated multi-omic analysis of GATA2 and GATA3 unveil their master regulatory roles on the trophoblast fate [RNA-seq]

Project description:The commitment and differentiation of human placental progenitor cells are crucial for a successful pregnancy, but the underlying regulatory mechanism remains poorly understood. Here we identified the transcription factor (TF), GATA2 and GATA3, exerting genetic redundancy, for cell fate decision of trophoblast cells. Using human expanded potential stem cells (hEPSC) as a model, we demonstrated that double knockout (DKO) of GATA2&3 failed for differentiation of trophoblast. Exogenous inducible over-expression GATA2&3 in DKO cells rescued trophoblast defects, in terms of gene expression.

2026-09-01 | GSE266534 | GEO

Integrated multi-omic analysis of GATA2 and GATA3 unveil their master regulatory roles on the trophoblast fate [scATAC-seq]

Project description:The commitment and differentiation of human placental progenitor cells are crucial for a successful pregnancy, but the underlying regulatory mechanism remains poorly understood. Here we identified the transcription factor (TF), GATA2 and GATA3, exerting genetic reduandency, for cell fate decision of trophoblast cells. At stage of EPSC, inducible overexpression GATA2&3 reprogrammed hEPSCs to trophoblast lineage.

2026-09-01 | GSE266535 | GEO

Integrated multi-omic analysis of GATA2 and GATA3 unveil their master regulatory roles on the trophoblast fate.

Project description:This SuperSeries is composed of the SubSeries listed below.

2026-09-01 | GSE266537 | GEO

Integrated multi-omic analysis of GATA2 and GATA3 unveil their master regulatory roles on the trophoblast fate.

Project description:Integrated multi-omic analysis of GATA2 and GATA3 unveil their master regulatory roles on the trophoblast fate.

| PRJNA1107521 | ENA

Integrated multi-omic analysis of GATA2 and GATA3 unveil their master regulatory roles on the trophoblast fate [HiCUT]

Project description:Integrated multi-omic analysis of GATA2 and GATA3 unveil their master regulatory roles on the trophoblast fate [HiCUT]

| PRJNA1166907 | ENA

Integrated multi-omic analysis of GATA2 and GATA3 unveil their master regulatory roles on the trophoblast fate [ATAC-seq]

Project description:Integrated multi-omic analysis of GATA2 and GATA3 unveil their master regulatory roles on the trophoblast fate [ATAC-seq]