Chemotherapy induces myeloid-driven spatial T-cell exhaustion in ovarian cancer

ABSTRACT: To characterize the spatial tumor microenvironment (TME) of high-grade serous ovarian cancer (HGSC) at the single cell level, we performed single-cell RNA sequencing (scRNA-seq) on 48 tumor or ascites samples from 29 HGSC patients. This data set includes paired scRNA-seq data from chemo-naive and post-neoadjuvant chemotherapy (IDS) samples of 22 HGSC patients.

ORGANISM(S): Homo sapiens

PROVIDER: GSE266577 | GEO | 2024/10/08

REPOSITORIES: GEO