Spatial transcriptome analysis for placental tissue of preeclampsia
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
PROVIDER: GSE266604 | GEO | 2025/11/25
REPOSITORIES: GEO
Dataset's files
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| GSE266604_RAW.tar | Raw | |||
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Similar Datasets
Project description:Bronchopulmonary dysplasia (BPD) continues to impact the health of preterm infants worldwide. Preeclampsia (PE), a placental-driven pregnancy disorder, has a strong clinical association with BPD risk. We hypothesize that preeclampsia causes a unique type of developmental lung injury that predisposes infants to an increased risk of BPD. Research on human placental tissues is needed to more clearly define the role of PE in developmental lung injury. A new approach to human placental analysis is spatial transcriptomics (Sp-Tr), a technique which produces spatially oriented gene expression data from cells in their native tissue environment.
2024-12-31 | GSE249899 | GEO
Project description:Preeclampsia (PE) is a common pregnancy disorder, and it complicates 5~7% of all pregnancies. At present, termination of pregnancy is the only curative strategy for PE. To explore a potential target for PE treatment, we collected placental tissue samples from patients with preeclampsia (PE) and normal pregnant women (N), and performed high-throughput RNA sequencing. We found that FOXP2 was significantly downregulated in placental samples of patients with PE compared with the controls.
2024-11-06 | GSE279757 | GEO
Project description:Preeclampsia (PE), which results from abnormal placentation, acts as a primary cause of maternal and neonatal morbidity and mortality. However, the cause of abnormal development of placenta remain poorly understood.Recently, it has been proposed that the genes that are differnetially expressed between PE and normal placenta tissues are associated with PE pathogenesis. To further elucidate the pathogenesis, we conducted transcriptional profiling of mRNA between PE and normal placenta tissues.
2023-04-23 | GSE149812 | GEO
Project description:Fibrosis are known as one of the characteristic pathological findings of placenta in preeclampsia (PE). The mechanism underlying tissue injury when placental stroma is exposed to hypoxia and inflammatory stimulation is unclear. We focused on the relationship between pathogenesis of PE and placental fibrosis, and investigated the changes of fibrosis related factors (FRFs) in placental stroma. The mRNA levels of fibrosis related factors in PE were higher than those in normal pregnancy (NP). Those under hypoxia and by TGF-β stimulation were more prominent in PE compared with NP. The contraction rate of PE had significantly higher than that of NP. The significant elevation of plasma level of TGF-β in PE was indicated compared with those in NP.
2017-05-18 | GSE99007 | GEO
Project description:Introduction: To determine the miRNA expression profile in pregnancies complicated by Preeclampsia (PE) and compare it to uncomplicated pregnancies. Methods: Seventeen placentas from women with PE, [all of them being late onset PE (LOPE)], as well as 17 placentas from uncomplicated pregnancies were analyzed using miRNA NGS. For statistical analyses the MATLAB® simulation environment was applied. The expression of miR-99b and miR-23b were verified using Quantitative Real-Time Polymerase Chain Reaction. Results: Two miRNAs were found dysregulated in PE complicated placentas. Statistical analysis revealed that miR-99b and miR-23b were under-expressed in complicated placentas as compared to controls. Discussion: Since specific miRNAs can differentiate complicated from uncomplicated pregnancies, they may be considered as putative PE-specific biomarkers.
2018-09-12 | GSE119799 | GEO
Project description:Background: Preeclampsia (PE) is a placental disease characterized by hypertension and proteinuria in pregnant women, which is associated with a high maternal and infantile morbidity. However, circulating biomarkers able to predict the prognosis of PE are lacking. Methods: Thirty-eight women were included in the study. They consisted of 19 patients with PE (13 with severe PE and 6 women with non-severe PE) and 19 gestational age-matched normal pregnancy controls. We measured coagulation pathway, endothelial responses and microparticle release and circulating gene expression in PE patient groups and normotensive controls. Results: The measurement of markers associated with coagulation pathway, endothelial activation and circulating microparticles enabled to discriminate PE from normal pregnancy but were not sufficient to distinguish severe from non-severe PE. PE patients also exhibited a specific transcriptional program distinct from that of control women and subtle differences were observed between severe and non-severe PE. Functional annotation of the up-modulated signature in PE highlighted two main functions related to ribosome and complement. Importantly, we found that 8 genes were specifically up-modulated in severe preeclampsia. Among these genes, the expression of VSIG4 was significantly increased in patients with severe preeclampsia in comparison with controls and patients with non-severe preeclampsia. Conclusion: Using transcriptional signatures of blood samples, we identified the gene encoding the estrogen receptor as a potential diagnostic marker of severe preeclampsia. In addition, the determination of this gene may improve the prognostic assessment of severe preeclampsia.
2014-05-14 | GSE48424 | GEO
Project description:Introduction: To determine the miRNA expression profile in placentas complicated by Preeclampsia (PE) and compare it to uncomplicated pregnancies. Methods: Sixteen placentas from women with PE, including 11 with early onset PE (EOPE) and 5 with late onset PE (LOPE), as well as 8 from uncomplicated pregnancies were analyzed using miRNA microarrays. For statistical analyses the MATLAB® simulation environment was applied. The over-expression of miR-518a-5p was verified using Quantitative Real-Time Polymerase Chain Reaction. Results: Overall, 44 miRNAs were found deregulateddysregulated in PE complicated placentas. Statistical analysis revealed that miR-431, miR-518a-5p and miR-124* were over-expressed in EOPE complicated placentas as compared to controls whereas miR-544 and miR-3942 were down-regulated in EOPE. When comparing the miRNA expression profile in cases with PE and PE- growth restricted fetuses (FGR), miR-431 and miR-518a-5p were found over-expressed in pregnancies complicated by FGR. Additionally, up- regulation of miR-124, miR-423-3p and miR-518a-5p was associated with proteinuria. Discussion: Specific miRNAs can differentiate EOPE and LOPE from uncomplicated pregnancies representing putative PE-specific diagnostic biomarkers. Among them, miR-518a-5p emerged as a potential diagnostic indicator for EOPE cases as well as for FGR and proteinuria associated PE complicated placentas designating its potential link to the severity of the disease.
2017-09-07 | GSE103542 | GEO
Project description:We have demonstrated that the etiology of preeclampsia (PE) is associated with protein aggregation, a pathologic paradigm observed in neurodegenerative diseases, and that impaired autophagy contributes to accumulation of protein aggregates. In search of therapeutic options for preeclampsia that inhibit protein aggregation and restore autophagy, we screened several small molecules and identified a class of disaccharides that may prove to be highly efficacious to treat and prevent this severe pregnancy complication. We used the human serum-based humanized PE mouse model to assess the effect of disaccharides on the onset of the syndrome. Mice were i.p. injected with vehicle, disaccharides (2g/kg) at gd9, gd11, and gd14. At gd17, urine was collected, blood pressure was measured, fetal weight was recorded, and placenta was collected and subjected to immunostaining and RNA sequencing. Trehalose and Lactotrehalose inhibited hypoxia-induced accumulation of aggregates and restored impaired autophagy-lysosomal machinery. Disaccharide administration significantly restored normal pregnancy features in PE mice as characterized by normalization of hypertension, proteinuria, growth restriction, and kidney injury. RNA-seq analysis identified some novel genes and pathways that are related to preeclampsia and normalized by disaccharides.
2023-11-01 | GSE202129 | GEO
Project description:Preeclampsia (PE) has become severe diseases that endangers the safety of mothers and fetuses worldwide.More studies on novel biomarkers for PE are inevitable. Data-independent acquisition proteomics, with five biological replicates, was used to investigate the protein expression profiles from placental tissues.
2021-07-14 | PXD027276 |