ChIP-seq analysis of RNA polymerase I inhibitor effect on Pol I and Pol II binding

ABSTRACT: Ribosome biosynthesis is essential for cancer growth and proliferation. This dependency is therapeutically exploitable by blocking the rate-limiting step, RNA polymerase I (Pol I) transcription. Here we investigated the effects of RNA Pol I inhibitor on binding of Pol I RPA1 and Pol II Rpb1 on genomic DNA.

ORGANISM(S): Homo sapiens

PROVIDER: GSE267504 | GEO | 2025/05/13

REPOSITORIES: GEO