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RNA-seq Analysis of the Longissimus Muscle of Laiwu and Yorkshire Pigs

ABSTRACT: Intramuscular fat (IMF) content is the determining factor for meat taste. To reveal the genetic basis of IMF content, genetic studies have made some progress in lean-type pig breeds, but fewer studies have been conducted in Chinese fat-type pigs. We selected Laiwu and Yorkshire pigs as models, and transcriptomic analysis was conducted on the longissimus dorsi muscle to investigate the gene expression patterns linked to high and low intramuscular fat (IMF) content. The purpose of the study was to determine the differences in intramuscular fat between the two breeds and identify the reasons for the differences. To further systematically investigate the potential biologic significance of phenotype divergence, the identified DEGs were annotated into multiple pathways based on KEGG bioinformatic databases (P < 0.05). According to the identified DEGs, the results revealed a number of enriched pathways in AMPK signaling pathway, cAMP signaling pathway, PPAR signaling pathway, and so on. Functional enrichment analysis showed that PPARγ, ADIPOQ, LEP, LIPE, SCD, FABP4 and PLIN1 were represented.

ORGANISM(S): Sus scrofa

PROVIDER: GSE268121 | GEO | 2025/04/18

REPOSITORIES: GEO

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