Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Transcriptomic analysis of kidney cortex following KLF6 induction

ABSTRACT: The goal of this study was to identify transcriptomic changes mediated by KLF6 induction 24 hours after aristolochic acid-induced acute kidney injury

ORGANISM(S): Mus musculus

PROVIDER: GSE268344 | GEO | 2025/05/08

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

ATAC-seq analysis of kidney cortex following KLF6 induction

Project description:The goal of this study was to identify chromatin changes mediated by KLF6 induction 24 hours after aristolochic acid-induced acute kidney injury

2025-05-08 | GSE268605 | GEO

Transcriptomic analysis of kidney cortex following the KLF6 induction

Project description:The goal of this study was to identify transcriptomic changes mediated by KLF6 induction in the setting of STZ-induced diabetic kidney disease

2024-08-02 | GSE171854 | GEO

Transcriptomic analysis of kidney cortex following KLF6 induction

Project description:Transcriptomic analysis of kidney cortex following KLF6 induction

| PRJNA1116249 | ENA

ATAC-seq analysis of kidney cortex following KLF6 induction

Project description:ATAC-seq analysis of kidney cortex following KLF6 induction

| PRJNA1117886 | ENA

Transcriptomic analysis of kidney cortex following the KLF6 induction

Project description:Transcriptomic analysis of kidney cortex following the KLF6 induction

| PRJNA721201 | ENA

ATAC analysis of kidney cortex following the KLF6 induction in podocytes

Project description:The goal of this study was to identify genome-wide chromatin accessibility changes caused by podocyte specific overexpression of KLF6 in STZ + UNX induced diabetic mouse model.

2024-08-02 | GSE230681 | GEO

ATAC analysis of kidney cortex following the KLF6 induction in podocytes

Project description:ATAC analysis of kidney cortex following the KLF6 induction in podocytes

| PRJNA962127 | ENA

Loss of proximal tubular Kruppel-like factor 6 (KLF6) is protective against AKI and CKD

Project description:Altered cellular metabolism in kidney proximal tubule (PT) cells plays a critical role in the development and progression of acute kidney injury (AKI). The transcription factor Krüppel-like factor 6 (KLF6) is rapidly and robustly induced in the PT after AKI, suggesting an early-inducible injury response gene. PT-specific Klf6 knockdown (Klf6PTKO) are protected from AKI and resulting fibrosis in mice. Combined RNA-sequencing and ChIP-sequencing demonstrated preserved expression of genes encoding branched chain amino acid (BCAA) catabolic enzymes in Klf6PTKO mice, with several of the genes also having KLF6 binding sites close to their transcription start sites. Conversely, inducible KLF6 overexpression suppressed expression of BCAA genes and exacerbated kidney injury and fibrosis in mice. Injured kidney cells could not respond to the BCAA catabolic activator BT2, and injured cells overexpressing KLF6 were less able to utilize BCAA. Thus, targeting KLF6-mediated suppression of BCAA catabolism may serve as key therapeutic target in AKI and kidney fibrosis.

2021-05-18 | GSE150656 | GEO

Role of POLR2A in kidney response to DNA damage

Project description:The role of POLR2A/RPB1 in kidney proximal tubule responses to DNA damage-induced acute kidney injury is unknown. We undertook treatment of HK2 cells with the DNA damaging agent aristolochic acid, with or without knockdown of POLR2A to determine the role of RPB1 in kidney cells.

2025-05-08 | GSE282647 | GEO

Analysis of gene expression changes when KLF6 is overexpressed in HepG2 cells

Project description:KLF6 was overexpressed using an adenoviral delivery system. Overexpression was confirmed at 12, 24, 48 and 72 hours post infection by RT-PCR and Western Blot analysis. Codelink Whole genome microarrays were used to analyse changes in expression resulting from KLF6 overexpression.

2014-08-22 | GSE60602 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data