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Expression data from human lung cancer cell lines with NEDD9 overexpression or NEDD9 knockdown

ABSTRACT: NEDD9 is important for lung cancer metastasis. However, the detailed mechanism remains elusive. Using the microarray data generated with human lung cancer cell lines with either NEDD9 overexpression or NEDD9 knockdown, we plan to idnetify important signal pathways regulated by NEDD9. This may explain how NEDD9 excutes its function in lung cancer. We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated genes during this process.

ORGANISM(S): Homo sapiens

PROVIDER: GSE26846 | GEO | 2013/02/21

SECONDARY ACCESSION(S): PRJNA135965

REPOSITORIES: GEO

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Expression data from human lung cancer cell lines with NEDD9 overexpression or NEDD9 knockdown

Project description:NEDD9 is important for lung cancer metastasis. However, the detailed mechanism remains elusive. Using the microarray data generated with human lung cancer cell lines with either NEDD9 overexpression or NEDD9 knockdown, we plan to idnetify important signal pathways regulated by NEDD9. This may explain how NEDD9 excutes its function in lung cancer. We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated genes during this process. Human lung cancer cell line A549, which has LKB1 loss-of-function mutation and increased expression of NEDD9, was used for two individual NEDD9 knockdown. Human lung cancer cell line CRL-5907, which has wild-type LKB1 and low NEDD9 expression level, was used for NEDD9 overexpression. The microarray was done in A549 cells, A549 cells with two different NEDD9 knockdown; CRL-5907 cells and CRL-5907 cells with NEDD9 overexpression.

2013-02-21 | E-GEOD-26846 | biostudies-arrayexpress

Expression data from SPAK transfected Caco2-BBE cells

Project description:Ste20-related proline/alanine rich kinase (SPAK) is involved in diverse function, such as the pathogenesis of inflammatory bowel diseases. It is very important to study the underlying mechanisms by which SPAK regulates the progress of IBD. We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated genes during this process. We transfected colon cancer modified cell line Caco2-BBE cells with SPAK plasmid and vector for RNA extraction and hybridization on VMSR Human 30k oligonucleotide microarrays.

2010-11-30 | E-GEOD-25641 | biostudies-arrayexpress

Identification of NEDD9 regulated genes in VCaP prostate cancer cells

Project description:NEDD9 gene (Neural precursor Expressed, Developmentally Down-regulated 9) encodes a member of the Cas family of signaling transduction molecules, which is a non-catalytic focal adhesion protein phosphorylated by FAK and Src and functions as a signaling hub to regulate downstream signaling, such as the AKT pathway. In cancers, NEDD9 regulates cell migration, epithelial-mesenchymal transition (EMT), invasion, and metastasis. Gene amplification of NEDD9 is commonly found in the advanced metastatic castration-resistant PCa (~3%) and neuroendocrine PCa (~15%), suggesting NEDD9 may play an important role in PCa progression. In order to characterize the global functions of NEDD9 in PCa cells, we performed RNA-seq analyses in VCaP cells (containing NEDD9 gene amplification) stably infected with shRNA against NEDD9 or non-targeting control (NTC).

2021-01-11 | GSE164531 | GEO

Expression data from human breast cancer cell MCF-7 and human gastric cancer cell SGC-7901

Project description:Piper longum L. is a well-known traditional antihyperlipidemic medicine，and it has ability to inhibit proliferation of cancer cells，potassium piperate (GBK) maybe have the same effect. We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated and down-regulated genes during this process.

2017-09-18 | GSE87440 | GEO

Expression data from CC10-rtta/teton-IL-13 tg mice fed with or without doxycycline

Project description:Morphogenesis of epithelial tissues relies on the precise developmental control of cell polarity and architecture. In the early Drosophila embryo, the primary epithelium forms during cellularisation, following a tightly controlled genetic programme where specific sets of genes are up-regulated. Some of them, for instance, control membrane invagination between the nuclei anchored at the apical surface of the syncytium. We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of regulated genes during EE.

2010-07-01 | GSE21267 | GEO

Expression data from renal collecting duct epithelial cell line

2018-03-08 | GSE111519 | GEO

Expression data from early Drosophila embryo

2006-01-01 | GSE3955 | GEO

Expression data from MCF-7 cells treated with 0, 50 and 100 uM Oxyresveratrol

Project description:We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated genes during this process.

2020-05-26 | GSE151139 | GEO

Expression data from KDM3A knockdown MDA-MB-231 cells

Project description:Breast cancer invasive growth, metastasis and therapeutic resistance affects the clinical ourcome. We explored the epigenetic mechanisms that control these process in breast cancer cell line, MDA-MB-231 by knocking down a lysine specific demethylase KDM3A We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated genes during this process.

2016-06-29 | GSE83818 | GEO

Tissue profiling of phosphodiesterases

Project description:We used microarrays to detail the global programme of gene expression underlying cellularisation and identified distinct classes of up-regulated genes during this process. Keywords: tissue profiling

2006-10-07 | GSE5983 | GEO

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