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RNA sequencing of THP-1 on Polyphenol-Mediated Redox-Active Hydrogel with H2S Gaseous-Bioelectric Coupling

ABSTRACT: A polyphenol-mediated redox-active algin/gelatin hydrogel encapsulating a conductive poly(3,4-ethylenedioxythiopene)-assembled polydopamine-mediated silk microfiber (PEDOT-PSF) network and a H2S sustained-release system utilizing bovine serum albumin nanoparticles (BNP) is developed. This hydrogel is found to reverse the hyperglycemic inflammatory microenvironment and promote functional tissue regeneration in periodontitis in diabetes. The RNA sequencing of THP-1 on Polyphenol-Mediated Redox-Active Hydrogel with H2S Gaseous-Bioelectric Coupling was conducted to explore the underlying mechanism.

ORGANISM(S): Homo sapiens

PROVIDER: GSE268476 | GEO | 2025/10/01

REPOSITORIES: GEO

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RNA sequencing of PDLSCs on Polyphenol-Mediated Redox-Active Hydrogel with H2S Gaseous-Bioelectric Coupling

Project description:A polyphenol-mediated redox-active algin/gelatin hydrogel encapsulating a conductive poly(3,4-ethylenedioxythiopene)-assembled polydopamine-mediated silk microfiber (PEDOT-PSF) network and a H2S sustained-release system utilizing bovine serum albumin nanoparticles (BNP) is developed. This hydrogel is found to reverse the hyperglycemic inflammatory microenvironment and promote functional tissue regeneration in periodontitis in diabetes. The RNA sequencing of PDLSCs on Polyphenol-Mediated Redox-Active Hydrogel with H2S Gaseous-Bioelectric Coupling was conducted to explore the underlying mechanism.

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RNA sequencing of PDLSCs on Polyphenol-Mediated Redox-Active Hydrogel with H2S Gaseous-Bioelectric Coupling

Project description:RNA sequencing of PDLSCs on Polyphenol-Mediated Redox-Active Hydrogel with H2S Gaseous-Bioelectric Coupling

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RNA sequencing of THP-1 on Polyphenol-Mediated Redox-Active Hydrogel with H2S Gaseous-Bioelectric Coupling

Project description:RNA sequencing of THP-1 on Polyphenol-Mediated Redox-Active Hydrogel with H2S Gaseous-Bioelectric Coupling

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QTL mapping reveals novel genes and mechanisms underlying variations in H2S production during alcoholic fermentation in Saccharomyces cerevisiae

Project description:Saccharomyces cerevisiae’s requirement of reduced sulfur to synthesise methionine and cysteine during alcoholic fermentation, is mainly fulfilled through the sulfur assimilation pathway. S. cerevisiae reduces sulfate into sulfur dioxide (SO2) and sulfide (H2S), whose overproduction is a major issue in winemaking, due to its negative impact on wine aroma. The amount of H2S produced is highly strain-specific and depends as well on the SO2 concentration, often added to the grape must. Applying a Bulk Segregant Analysis to a 96 strain-progeny derived from two strains with different ability to produce H2S, and comparing the allelic frequencies along the genome of pools of segregants producing opposite H2S quantities, we identified two causative regions involved in H2S production in the presence of SO2. A functional genetic analysis allowed the identification of variants in four genes: ZWF1, ZRT2, SNR2 and YLR125W, able to impact H2S formation, involved in functions and pathways until now not associated with sulfur metabolism. This data points that redox status and zinc homeostasis are linked to H2S formation in wine fermentation conditions and provides new insights into the regulation of H2S production during wine fermentation, giving a new vision of the interplay between the sulfur assimilation pathway and cell metabolism. This archive contains the transcriptome data of the result of allelic swp for three genes : ZWF1, ZRT2, YLR125w under fermentation.

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Hydrogen sulfide (H2S) modulates lifespan of C.elegans

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Mycobacterium tuberculosis H2S functions as a sink to modulate central metabolism, bioenergetics, and drug susceptibility

Project description:H2S is a potent gasotransmitter in eukaryotes and bacteria. Host-derived H2S was shown to profoundly alter M. tuberculosis (Mtb) energy metabolism and growth. However, compelling evidence for endogenous production of H2S and its role in Mtb physiology is lacking. We show that multi-drug-resistant and drug-susceptible clinical Mtb strains produce H2S, whereas H2S production in non-pathogenic M. smegmatis is barely detectable. We identified Rv3684 (Cds1) as an H2S-producing enzyme in Mtb and show that cds1 disruption reduces, but does not eliminate H2S production, suggesting the involvement of multiple genes in H2S production. We identified endogenous H2S to be an effector molecule that maintains bioenergetic homeostasis by regulating respiration. Importantly, H2S plays a key role in central metabolism by modulating the balance between oxidative phosphorylation and glycolysis, and functions as a sink to recycle sulfur atoms back to cysteine to maintain sulfur homeostasis. Lastly, Mtb-generated H2S regulates redox homeostasis and susceptibility to the anti-TB drugs clofazimine and rifampicin. These findings reveal previously unknown facets of Mtb physiology and have implications for routine laboratory culturing, understanding drug susceptibility, and improved diagnostics.

2021-08-16 | PXD022969 | Pride

C.elegans H2S RNA-seq time course

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2023-12-31 | E-MTAB-13296 | biostudies-arrayexpress

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