The Hippo pathway and p27Kip1 cooperate to suppress sensory receptor regeneration in the organ of Corti and the retina.
Ontology highlight
ABSTRACT: The mammalian auditory sensory organ, the organ of Corti, has no capacity for regenerating lost hair cells, leading to permanent hearing impairment. In this study, we demonstrate that auditory supporting cells resist Yap activation after Hippo inhibition and uncover the molecular mechanism maintaining quiescence in the adult cochlear supporting cells.
ORGANISM(S): Mus musculus
PROVIDER: GSE268504 | GEO | 2025/04/23
REPOSITORIES: GEO
ACCESS DATA