Regenerative neurogenesis in adult zebrafish brain after neurodegeneration

ABSTRACT: Alzheimer's disease (AD) is a debilitating neurodegenerative disease in which accumulation of toxic amyloid-β42 (Aβ42) peptides leads to synaptic degeneration, inflammation, neuronal death, and learning deficits. Zebrafish (Danio rerio) is a regenerative organism, and we can learn the basic molecular programs with which we could design therapeutic approaches to tackle AD. By using our amyloid toxicity model in adult zebrafish brain by injecting synthetic Aβ42, we investigate the neurodegeneration phenotypes reminiscent of human brain pathology (e.g., cell death, microglial activation, synaptic degeneration, and memory deficits) in single cell level.

ORGANISM(S): Danio rerio

PROVIDER: GSE268721 | GEO | 2026/07/02

REPOSITORIES: GEO