Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Novel function of cholecystokinin (CCK): Mediator between feeding and gonadal development

ABSTRACT: We used single cell RNA sequencing (scRNA-seq)to analyze the pituitary cells in Ctenopharyngodon idellus

ORGANISM(S): Ctenopharyngodon idella

PROVIDER: GSE269034 | GEO | 2025/01/29

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Novel function of cholecystokinin (CCK): Mediator between feeding and gonadal development

Project description:We used single cell RNA sequencing (scRNA-seq)to analyze the hypothalamu cells in Ctenopharyngodon idellus

2025-01-29 | GSE268914 | GEO

Cholecystokinin (CCK) Is a Mediator Between Nutritional Intake and Gonadal Development in Teleosts.

Project description:Nutritional intake is closely linked to gonadal development, although the mechanisms by which food intake affects gonadal development are not fully understood. Cholecystokinin (CCK) is a satiety neuropeptide derived from the hypothalamus, and the present study observed that hypothalamic CCK expression is significantly influenced by food intake, which is mediated through blood glucose levels. Interestingly, CCK and its receptors were observed to exhibit a high expression in the hypothalamus-pituitary-gonad (HPG) axis of grass carp (Ctenopharyngodon idellus), suggesting that CCK is potentially involved in regulating fish reproduction through the HPG axis. Further investigations revealed that CCK could significantly stimulate the expression of gonadotropin-releasing hormone-3 (GnRH3) in the hypothalamus. In addition, single-cell RNA sequencing showed that cckrb was highly enriched in pituitary follicle-stimulating hormone (FSH) cells. Further study confirmed that CCK can significantly induce FSH synthesis and secretion in primary cultured pituitary cells. Additionally, with primary cultured ovary cells as a model, the in vitro experiment demonstrated that CCK directly induces the expression of lhr, fshr, and cyp19a1a mRNA. This indicates that hypothalamic CCK may act as a nutrient sensor involved in regulating gonadal development in teleosts.

| S-EPMC11763773 | biostudies-literature

Novel function of cholecystokinin (CCK): Mediator between feeding and gonadal development

Project description:Novel function of cholecystokinin (CCK): Mediator between feeding and gonadal development

| PRJNA1119996 | ENA

Novel function of cholecystokinin (CCK): Mediator between feeding and gonadal development

Project description:Novel function of cholecystokinin (CCK): Mediator between feeding and gonadal development

| PRJNA1119449 | ENA

High Temperature on Immune Response of Grass Carp

Project description:Effect of High Temperature on Immune Response of Grass Carp (Ctenopharyngodon idellus) by Transcriptome Analysis

2016-03-16 | GSE79265 | GEO

MeDIP-seq of Ctenopharyngodon idellus kidney cells after grass carp reovirus infection

Project description:MeDIP-seq of Ctenopharyngodon idellus kidney cells after GCRV infected 8 hours.

2024-05-11 | E-MTAB-13003 | biostudies-arrayexpress

RNA-seq of Ctenopharyngodon idellus kidney cells after grass carp reovirus infection

Project description:RNA-seq of Ctenopharyngodon idellus kidney cells after GCRV infected 4hours and 8 hours.

2024-05-11 | E-MTAB-13002 | biostudies-arrayexpress

Ctenopharyngodon idella

Project description:Ctenopharyngodon idellus

| PRJNA1069875 | ENA

High Temperature on Immune Response of Grass Carp

Project description:Effect of High Temperature on Immune Response of Grass Carp (Ctenopharyngodon idellus) by Transcriptome Analysis To understand the immune response mechanisms of this fish in high temperature circumstance, the transcriptomic profiles of the spleens from grass carp groups undergoing heat stress and normal temperature were investigated.

2016-03-16 | E-GEOD-79265 | biostudies-arrayexpress

Ctenopharyngodon idella breed:Eukaryotic breed

Project description:grass carp (Ctenopharyngodon idellus) _DNA_2bRAD_growth_QTL

| PRJNA496416 | ENA