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Methylation Profiling for Pediatric Pineal Parenchymal Tumors

ABSTRACT: Pineal parenchymal body tumors are rare central nervous system tumors with a variety of presentations ranging from well-differentiated low-grade tumors to undifferentiated highly aggressive tumors. Recent molecular classification has described the heterogeneity among these tumors, particularly among pineoblastomas (PB) and papillary tumors of intermediate differentiation (PPTID). Herein, we describe the methylation profile for 20 pediatric pineal parenchymal tumors using Illumina Infinium Methylation EPIC BeadChip array and correlate it with the patients’ clinical data. Our findings support that these tumors are diverse, incorporating novel entities with distinct clinical features and the presence of medulloblastomas outside the posterior fossa.

ORGANISM(S): Homo sapiens

PROVIDER: GSE269319 | GEO | 2025/06/06

REPOSITORIES: GEO

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