Transcriptomics

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Analysis of tumor infiltrating lymphocytes from murine PAN02 subcutaneos tumors under SMAC mimetic and BET inhibitor treatment


ABSTRACT: A multi-omic analysis of CITE-seq and advanced flow cytometry of a syngeneic model of PDAC unveils distinct phenotypic correlations of augmented anti-tumor immunity and a substantially reduced immunosuppressive tumor microenvironment (TME). This study presents BETi and SMACm as a promising drug combination for cancer patients with a multi-layered impact on both tumor cell intrinsic, as well as TME-dependent mechanisms.

ORGANISM(S): Mus musculus

PROVIDER: GSE269602 | GEO | 2025/07/07

REPOSITORIES: GEO

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