Metabolic programs drive function of therapeutic natural killer (NK) cells in low oxygen tumor microenvironments

ABSTRACT: Limited oxygen in solid tumors poses a challenge to successful immunotherapy with NK cells. NK cells have impaired cytotoxicity when cultured in hypoxia (1% oxygen), but not physiologic or atmospheric oxygen (>5%). We sought to analyze the impact of oxygen concentrations on human NK cell biology to determine what factors were driving loss of cytotoxicity and where there were opportunities to overcome hypoxia-induced dysfunction in NK cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE269629 | GEO | 2024/11/06

REPOSITORIES: GEO