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Comprehensive data for studying serum exosome microRNA transcriptome in Parkinson's disease patients

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE269781 | GEO | 2024/07/26

REPOSITORIES: GEO

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Comprehensive data for studying serum exosome microRNA transcriptome in Parkinson's disease patients.

Project description:Parkinson's disease (PD), the second most prevalent neurodegenerative disorder, was classically attributed to alpha-synuclein aggregation and consequent loss of dopaminergic neurons in the substantia nigra pars compacta. Recently, emerging evidence suggested a broader spectrum of contributing factors, including exosome-mediated intercellular communication, which can potentially serve as biomarkers and therapeutic targets. However, there is a remarkable lack of comprehensive studies that connect the serum exosome microRNA (miRNA) transcriptome with demographic, clinical, and neuroimaging data in PD patients. Here, we present serum exosome miRNA transcriptome data generated from four cohort studies. Two of these studies include 96 PD patients and 80 age- and gender-matched controls, with anonymised demographic, clinical, and neuroimaging data provided for PD patients. The other two studies involve 96 PD patients who were evaluated both before and after one year of treatment with rasagiline, a widely prescribed anti-parkinsonism drug. Together, the datasets provide a valuable source for understanding pathogenesis and discovering biomarkers and therapeutic targets in PD.

| S-EPMC11480472 | biostudies-literature

Comprehensive data for studying serum exosome microRNA transcriptome in Parkinson's disease patients

Project description:Comprehensive data for studying serum exosome microRNA transcriptome in Parkinson's disease patients

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Effect of rasagiline on the serum exosome miRNA transcriptome of Parkinson's disease patients (2023)

Project description:Background: Parkinson's disease (PD), a neurodegenerative disease characterised by bradykinesia, rest tremor and rigidit, affects approximately 6.1 million people worldwide. Although its aetiology was attributed to accumulation of misfolded alpha-synuclein species and subsequent loss of dopaminergic neurons in the substantia nigra, recently, systemic factors contributing to its initiation and progression have gained increasing recognition. Specifically, exosomes, a kind of extracellular vesicles in the size range of ∼30 to ∼200 nm, have been highlighted as crucial mediators in orchestrating the intricate intercellular communication in PD. Among its cargos, miRNAs, with its ability to promote target mRNA degradation and inihibit translation, have been identiifed as promising biomarkers and therpaeutic targets. Nonetheless, the effect of anti-parkinsonism medication on the serum exosome miRNA profiles of PD patients remain lagrely unexplored. Objective: To examine the effects of rasagiline, a potentially neuroprotective monoamine oxidase B inihibitor, on the serum exosome miRNA profile of PD patients.

2024-07-26 | GSE269779 | GEO

Effect of rasagiline on the serum exosome miRNA transcriptome of Parkinson's disease patients (2022)

2024-07-26 | GSE269777 | GEO

Effect of rasagiline on the serum exosome miRNA transcriptome of Parkinson's disease patients (2021)

2024-07-26 | GSE269776 | GEO

Effect of rasagiline on the serum exosome miRNA transcriptome of Parkinson's disease patients (2020)

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Effect of rasagiline on the serum exosome miRNA transcriptome of Parkinson's disease patients (2021)

Project description:Effect of rasagiline on the serum exosome miRNA transcriptome of Parkinson's disease patients (2021)

| PRJNA1123682 | ENA

Effect of rasagiline on the serum exosome miRNA transcriptome of Parkinson's disease patients (2023)

Project description:Effect of rasagiline on the serum exosome miRNA transcriptome of Parkinson's disease patients (2023)