Transcriptomics

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Unlocking the aggressive potential of ZNF217 Exon-4 Skipping isoform in breast cancer and its contribution to bone metastasis


ABSTRACT: Breast cancer remains a major health concern worldwide, with bone metastases presenting a significant threat to patient outcomes. Generation of aberrant splicing variants with oncogenic potential are involved in the development and progression of tumors. this study identifies ZNF217-ΔE4 as a new oncogenic splice variant in breast cancer mediating cell aggressiveness and bone marrow homing, as well as a new indicator of the development of bone metastases. ZNF217-ΔE4 thus represents a novel candidate therapeutic target and a new valuable biomarker in the management of breast cancers, particularly in patients with a higher risk of developing bone metastases

ORGANISM(S): Homo sapiens

PROVIDER: GSE269986 | GEO | 2025/06/15

REPOSITORIES: GEO

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