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MicroRNA miR-20a-5p targets CYCS to inhibit apoptosis in hepatocellular carcinoma.

ABSTRACT: Hepatocellular carcinoma (HCC) is a cancer with global impact and largely refractory to current treatments. Novel treatment options are therefore urgently needed. MicroRNAs play important regulatory roles in HCCs and are emerging as promising therapeutic options against HCC. We identified tumor suppressor miRNAs that may attenuate tumor development and contribute to HCC regression. We identified and validated miR-20a-5p as a promising oncogenic miRNA in HCC. To understand how miR-20a-5p affects the global landscape of gene expression, we transfected Huh7 human hepatoma cells with either the scramble control, or an inhibitor against miR-20a-5p and performed mRNA expression profiling.

ORGANISM(S): Homo sapiens

PROVIDER: GSE270068 | GEO | 2025/12/31

REPOSITORIES: GEO

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