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Schistosoma mansoni developmental stages

ABSTRACT: Transcriptional profiling using two subsequent developmental stages of Schistosoma mansoni (Egg vs. Miracidium; Cercaria vs. 7-days-old Schistosomulum; 7-days-old Schistosomulum vs. Adult worms

ORGANISM(S): Schistosoma mansoni

PROVIDER: GSE27026 | GEO | 2011/04/30

SECONDARY ACCESSION(S): PRJNA137687

REPOSITORIES: GEO

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Schistosoma mansoni developmental stages

Project description:Transcriptional profiling using two subsequent developmental stages of Schistosoma mansoni (Egg vs. Miracidium; Cercaria vs. 7-days-old Schistosomulum; 7-days-old Schistosomulum vs. Adult worms Two conditions experiment; Developmental Stage 1 vs. Developmental Stage 2

2011-04-30 | E-GEOD-27026 | biostudies-arrayexpress

TGF-beta treated Schistosoma mansoni

Project description:Transcriptional profiling of TGF-beta treated Schistosoma mansoni adult worms vs. Non-treated Schistosoma mansoni adult worms

2012-02-20 | GSE27050 | GEO

Schistosoma mansoni cercarial head and tail LC-MSMS

Project description:Label-Free Quantitative analysis of the proteome of infectious cercaria of the species Schistosoma mansoni. The proteome of the cercarial head and cercarial tail were compared to elucidate differences in stored proteins that control biological function during development.

2022-02-17 | PXD026435 | Pride

TGF-beta treated Schistosoma mansoni

Project description:Transcriptional profiling of TGF-beta treated Schistosoma mansoni adult worms vs. Non-treated Schistosoma mansoni adult worms Two conditions (treated vs. Non-treated) with three biological samples of treated worms (TGF1, 4 and 5) and two biological samples of non-treated worms that were pooled into a single sample (pool). For each sample (three treated or polled non-treated) were performed four technical replicas

2012-02-20 | E-GEOD-27050 | biostudies-arrayexpress

Gene expression profiles of Schistosoma japonicum in four developmental stages

Project description:In the complex lifecycle of schistosomes, four developmental stages are closely associated with their definitive hosts: cercaria (infective stage), schistosomula and adult worm (parasitic stages), egg (pathogenic- and pathophoresis-stage). We have examined the gene expression profiles of Schistosoma japonicum in the four developmental stages. Genes with different expression patterns were identified and the information obtained will help indentify new anti-schistosomal intervention targets in the future.

2017-02-09 | GSE57143 | GEO

Schistosoma mansoni

Project description:Schistosoma mansoni developmental stages

| PRJNA137687 | ENA

Schistosoma mansoni

Project description:Schistosoma mansoni transcriptome project

| PRJNA64591 | ENA

Schistosoma mansoni

Project description:Schistosoma mansoni population exomics

| PRJNA439266 | ENA

Schistosoma mansoni strain:BH

Project description:Schistosoma mansoni Egg, Adult Male and Female Transcriptome Profiling

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Effect of human TNF-alpha on adult Schistosoma mansoni gene expression profile

Project description:Schistosoma mansoni is the major causative agent of schistosomiasis in the Americas. This parasite takes advantage from host signaling molecules such as cytokines and hormones to complete its development inside the host. TNF-α is the most important cytokine involved in the inflammatory response when cercaria, the infective stage, penetrates the human skin and a severe inflammatory response is started. In this work the authors describe the complete sequence of a possible TNF-α receptor in S. mansoni and detect that the receptor is most highly expressed in cercaria among all life cycle stages. In an attempt to mimic the situation at the site of skin penetration cercariae have been mechanically transformed in vitro into schistosomula and immediately exposed to human TNF-α . Exposure of these early schistosomula to the human hormone caused a large-scale change in the expression of parasite genes. Exposure of adult worms to human TNF-α caused gene expression changes as well, although the set of parasite altered genes was entirely different from that of schistosomula. This work increases the number of known signaling pathways of the parasite, and opens new perspectives into understanding the molecular components of TNF-α response as well as possibly interfering with parasite-host interaction.

2009-12-15 | GSE16261 | GEO

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