Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE270290 | GEO | 2024/06/26

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms.

Project description: Not available

| S-EPMC11530234 | biostudies-literature

Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms.

Project description: Not available

| S-EPMC10557775 | biostudies-literature

Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms (preliminary experiment)

Project description:Aging is associated with a number of physiologic changes including perturbed circadian rhythms; however, mechanisms by which rhythms are altered remain unknown. To test the idea that circulating factors mediate age-dependent changes in peripheral rhythms, we compared the ability of human serum from young and old individuals to synchronize circadian rhythms in culture.We collected blood from apparently healthy young (age 25-30) and old (age 70-76) individuals and used the serum to synchronize cultured fibroblasts. We found that young and old sera are equally competent at initiating robust ~24h oscillations of a luciferase reporter driven by clock gene promoter. However, cyclic gene expression is affected, such that young and old sera promote cycling of sets of different genes. Genes that lose rhythmicity with old serum entrainment are associated with oxidative phosphorylation and Alzheimer’s Disease as identified by STRING and IPA analyses. Also, the expression of cycling genes associated with cholesterol biosynthesis increased in the cells entrained with old serum. Genes involved in the cell cycle and transcription/translation remain rhythmic in both conditions, We did not observe a global difference in the distribution of phase between groups, but found that peak expression of several clock-controlled genes (PER3, NR1D1, NR1D2, CRY1, CRY2, and TEF) lagged in the cells synchronized ex vivo with old serum. Taken together, these findings demonstrate that age-dependent blood-borne factors affect peripheral circadian rhythms in cells and have the potential to impact health and disease via maintaining or disrupting rhythms respectively.

2024-06-26 | GSE270289 | GEO

Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms (main experiment)

2024-06-26 | GSE270288 | GEO

Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms

Project description:Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms

| PRJNA1126127 | ENA

Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms (preliminary experiment)

Project description:Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms (preliminary experiment)

| PRJNA1126134 | ENA

Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms (main experiment)

Project description:Evidence for a role of human blood-borne factors in mediating age-associated changes in molecular circadian rhythms (main experiment)

| PRJNA1126131 | ENA

"Cancersensor": Circadian Rhythms

Project description:Observational, non randomized study aimed at measuring the circadian rhythms in the urinary concentrations of physiological modified nucleosides in 30 patients with metastatic colorectal cancer and in 30 age and sex-matched healthy subjects.

| 2132582 | ecrin-mdr-crc

Manipulating circadian clock neuron firing rate resets molecular circadian rhythms and behavior.

Project description: Not available

| S-EPMC4502919 | biostudies-literature

Robustness of circadian rhythms with respect to molecular noise.

Project description: Not available

| S-EPMC117364 | biostudies-literature