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Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE270297 | GEO | 2025/01/10

REPOSITORIES: GEO

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Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability.

Project description: Not available

| S-EPMC11837984 | biostudies-literature

Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability [repliATAC-seq]

Project description:In the process of DNA replication, the first steps in restoring the chromatin landscape involve parental histone recycling and new histone deposition. Disrupting histone recycling to either the leading or lagging strand induces asymmetric histone inheritance, impacting epigenome maintenance and cellular identity. However, the order and kinetics of these effects remain elusive. Here, we employ inducible mutants to dissect the early and late consequences of impaired histone recycling. Simultaneous disruption of both leading (POLE4) and lagging strand (MCM2-2A) recycling pathways impairs transmission of parental histones to newly synthesized DNA, with release of some parental histones to the soluble pool. Subsequently, H3K27me3 accumulates aberrantly during chromatin restoration in a manner preceding gene expression changes. Loss of histone inheritance and the ensuing chromatin restoration defects alter gene expression in embryonic stem cells, challenges differentiation programs and cell viability. Our findings demonstrate the importance of efficient transmission of histone-based information during DNA replication for maintaining chromatin landscapes, differentiation potential, and cellular viability.

2025-01-10 | GSE279382 | GEO

Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability [SCAR-seq]

2025-01-10 | GSE270279 | GEO

Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability [RNA-Seq]

2025-01-10 | GSE270144 | GEO

Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability [ChOR-seq]

2025-01-10 | GSE270291 | GEO

Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability

Project description:Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability

| PRJNA1126146 | ENA

Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability [ChOR-seq]

Project description:Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability [ChOR-seq]

| PRJNA1126142 | ENA

Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability [repliATAC-seq]

Project description:Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability [repliATAC-seq]

| PRJNA1172326 | ENA

Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability [SCAR-seq]

Project description:Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability [SCAR-seq]

| PRJNA1126116 | ENA

Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability [RNA-Seq]

Project description:Disabling leading and lagging strand histone transmission results in parental histones loss and reduced cell plasticity and viability [RNA-Seq]

| PRJNA1125325 | ENA

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