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Gene epression analyses on pre- and post-treatment samples obtained from AML patients who respond or failed to respond to Venetoclax/Decitabine treatment

ABSTRACT: To elucidate the underlying mechanisms of resistance to venetoclax and dexitabine combination therapy, we performed transcriptomic analysis of VEN/DEC pre- and post-treatment samples from AML patients enrolled in the DEC10-VEN clinical trial (NCT03404193). We have reported that AML cells from non-responders show a significant upregulation of the mRNA expression of the fatty acid metabolism activator PPARG (Peroxisome Proliferator-Activated Receptor γ) after VEN/DEC treatment.

ORGANISM(S): Homo sapiens

PROVIDER: GSE270621 | GEO | 2025/08/06

REPOSITORIES: GEO

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AML patients for in vivo study of venetoclax plus AraC treatment

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Gene epression analyses on pre- and post-treatment samples obtained from AML patients who respond or failed to respond to Venetoclax/Decitabine treatment

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