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CCSK

ABSTRACT: Clear cell sarcoma of the kidney (CCSK), the second most common renal tumor in children, poses significant diagnostic challenges. No diagnostic positive markers are available, and the pathogenesis of CCSK remains an enigma. To address these challenges, the gene expression patterns of fourteen CCSKs were compared to fifteen Wilms tumors (WT) and three fetal kidney samples using oligonucleotide arrays. Keywords: other

ORGANISM(S): Homo sapiens

PROVIDER: GSE2712 | GEO | 2005/09/22

SECONDARY ACCESSION(S): PRJNA92367

REPOSITORIES: GEO

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CCSK

Project description:Clear cell sarcoma of the kidney (CCSK), the second most common renal tumor in children, poses significant diagnostic challenges. No diagnostic positive markers are available, and the pathogenesis of CCSK remains an enigma. To address these challenges, the gene expression patterns of fourteen CCSKs were compared to fifteen Wilms tumors (WT) and three fetal kidney samples using oligonucleotide arrays. Keywords: other. This dataset is part of the TransQST collection.

2005-09-22 | E-GEOD-2712 | biostudies-arrayexpress

Gene expression profiling of Wilms tumors

Project description:The global gene expression pattern of Wilms tumors in comparison with clear cell sarcoma of the kidney (CCSK) and non-neoplastic fetal and adult kidneys.

2016-02-04 | GSE73209 | GEO

Homo sapiens

Project description:TARGET: Kidney - Clear Cell Sarcoma of the Kidney (CCSK)

| PRJNA89537 | ENA

EGAS00001003445-sc-2021-04-23T07:29:39Z - samples

Project description:This data set contains single cell transcriptomes generated using the chromium 10X platform from both fresh cells and nuclei. The samples measured are derived from children with Wilms tumour, Clear Cell Sarcoma of the Kidney (CCSK), or Malignant Rhabdoid Tumours.

| EGAD00001007572 | EGA

Dysregulated Signalling leads to altered cell migration: an oncogenic basis for the development of CCSK

Project description:The oncogenic mechanisms and tumour biology underpinning Clear Cell Sarcoma of Kidney (CCSK), the second commonest paediatric renal malignancy, are poorly understood and currently therapy depends heavily on Doxorubicin with cardiotoxic side-effects. Previously, we characterised the balanced t(10;17)(q22;p13) chromosomal translocation, identified at that time as the only recurrent genetic aberration in CCSK. This translocation results in an in-frame fusion of the YWHAE (encoding 14-3-3e) and NUTM2 genes, with a somatic incidence of 12%. Clinico-pathological features of that cohort suggested that this aberration might be associated with higher stage and grade disease. Since no primary CCSK cell line exists, we generated various stably transfected cell lines containing doxycycline-inducible HA-tagged-YWHAE-NUTM2, in order to study the effect of expressing this transcript. 14-3-3e-NUTM2-expressing cells exhibited significantly greater cell migration compared to mock-treated controls. Gene and protein expression studies conducted in parallel on this model system suggested dysregulation of signalling pathways as a basis to the migration changes. Importantly, by blocking these signalling pathways using anti-EGFR, anti-IGF1R and anti-PDGFa neutralising antibodies, the migratory advantage conferred by transcript expression was abrogated. These results support 14-3-3e-NUTM2 expression as a contributor to CCSK tumorigenesis and provide avenues for the exploration of novel therapeutic approaches in CCSK.

2018-01-10 | GSE98757 | GEO

Clear cell sarcoma of the kidney demonstrates an embryonic signature indicative of a primitive nephrogenic origin

Project description:Gene expression profiling of CCSK in comparison with non-neoplastic foetal and adult kidney

2014-08-22 | GSE49972 | GEO

Aberrant epigenetic regulation in clear cell sarcoma of the kidney (CCSK)

Project description:Methylation array analyses of 30 CCSKs in comparison with 18 Wilms tumours and normal non-malignant kidneys (2 foetal kidneys and 6 adult kidneys) revealed CCSK tumour DNA to be globally hypermethylated. Four CCSKs, two WTs, two foetal kidneys and 2 adult kidneys were analysed as technical duplicates on different arrays.

2016-02-04 | GSE73187 | GEO

Receptor Tyrosine Kinase Activation in Infantile Fibrosarcoma/Congenital Mesoblastic Nephroma

Project description:The goal of this study is to identify downstream pathways, diagnostic markers, and potential therapeutic targets for IFS/CMN. Global gene expression of 14 cellular mesoblastic nephromas/infantile fibrosarcoma was compared with 10 RT, 16 clear cell sarcomas of the kidney, and 15 Wilms tumors using Affymetrix U133A arrays to identify genetic pathways that clarify the pathogenesis of Rhabdoid Tumors and to discover new therapeutic targets for these tumors

2012-02-29 | E-GEOD-30946 | biostudies-arrayexpress

Chromatin Analysis of Wilms Tumor Highlights Stem Cell Properties and a Renal Developmental Network

Project description:Wilms tumors are pediatric cancers thought to arise from kidney-specific stem cells. In order to identify transcriptional and epigenetic mechanisms that drive these malignant cells, we compared genomewide chromatin profiles of Wilms tumors to embryonic stem (ES) cells and normal kidney. Data represent examination of genome-wide chromatin modifications in primary Wilms tumors, fetal and mature kidney.

2010-05-05 | E-GEOD-20512 | biostudies-arrayexpress

Chromatin Analysis of Wilms Tumor Highlights Stem Cell Properties and a Renal Developmental Network

2010-05-05 | GSE20512 | GEO

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