Genomics

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Histone H3.14 variant is an early player in the abiotic stress response of Arabidopsis


ABSTRACT: Here we have focused on H3.14, a H3 variant which is expressed at very low levels under normal growth conditions. We found that it is expressed rapidly and transiently after abiotic stress in cells of the transition zone of the root, a subset of cells that seem to be responsive to the stress stimuli. To define its functional relevance we analyzed the phenotype of htr14 mutants and found that, contrary to the growth arrest phenotype of wild type plants, they show sustained growth in the presence of stress. The euchromatic localization of H3.14 suggested that it might be involved in transcriptional control. ChIP-seq identification of H3.14 genome-wide location after salt stress and RNA-seq of the htr14 mutant led us to identify three major H3.14 binding patterns that are associated with distinct clusters of genes involved in the early activation response to abiotic stress, in arresting cell growth and in maintenance of cellular homeostasis during abiotic stress. We conclude that the histone variant H3.14 is part of the early response required for the fast rewiring of transcriptional regulation after abiotic stress.

ORGANISM(S): Arabidopsis thaliana

PROVIDER: GSE271266 | GEO | 2025/06/05

REPOSITORIES: GEO

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