Transcriptomics

Dataset Information

25

Gene expression profiles of mouse Blimp1 +/gfp and Blimp1 gfp/gfp regulatory T cells


ABSTRACT: Regulatory T (Treg) cells are required for peripheral tolerance. Recent evidence indicates that Treg cells can adopt specialized differentiation programs in the periphery that are controlled by transcription factors usually associated with T helper differentiation. We demonstrate that expression of the transcription factor Blimp1 defines a population of Treg cells that localize predominantly to mucosal sites and produces IL-10. Blimp1 is required for IL-10 production by these cells and for their tissue homeostasis. A list of differentially expressed genes were identified from this whole-genome expression profiling experiment. Overall design: Mouse Blimp1 +/gfp and Blimp1 gfp/gfp regulatory T cells were analyzed. Three replicates each.

INSTRUMENT(S): Illumina mouse-6 v1.1 expression beadchip

ORGANISM(S): Mus musculus  

SUBMITTER: Wei Shi  

PROVIDER: GSE27143 | GEO | 2011-02-09

SECONDARY ACCESSION(S): PRJNA137577

REPOSITORIES: GEO

Similar Datasets

2011-02-09 | E-GEOD-27143 | ArrayExpress
| GSE121764 | GEO
2016-01-18 | E-GEOD-70981 | ArrayExpress
| GSE102967 | GEO
2016-06-15 | E-GEOD-75724 | ArrayExpress
| PRJNA137577 | ENA
| GSE90824 | GEO
| GSE90625 | GEO
2017-04-19 | PXD006251 | Pride
| PRJEB1759 | ENA