Genomics

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Expression data from murine vaginal samples following adjuvant treatment


ABSTRACT: Vaccine research today is focused on using safer, highly purified or recombinant antigens with poor immunogenicity, which has created a need for potent adjuvants. Rational design of effective and safe mucosal adjuvants for human use necessitates a thorough understanding of the mode of action of successful candidate adjuvants. We used microarray to comprehend the molecular signatures of mucosal adjuvants in the mouse vagina. The adjuvants studied, CpG-ODN and α-GalCer have previously been shown to be potent mucosal adjuvants in mice when administrered together with a glycoprotein from HSV-2.

ORGANISM(S): Mus musculus

PROVIDER: GSE27149 | GEO | 2011/12/30

SECONDARY ACCESSION(S): PRJNA137563

REPOSITORIES: GEO

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