Gut microbiome-derived LPS aggravated cognitive impairment by promoting systemic inflammation via the TLR4/MyD88/NF-κB signaling pathway in hypoxic-ischemic neonatal rats

ABSTRACT: Hypoxic ischemic brain damage (HIBD) is the primary cause of neurological deficits in neonates, leading to long-term cognitive impairment. Recent studies have demonstrated that gut microbiota plays a crucial role in the development of cognitive impairment after brain injury, known as the microbiota-gut-brain axis.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE271722 | GEO | 2025/07/01

REPOSITORIES: GEO