Sexual dimorphism of the synovial transcriptome underpins greater PTOA disease severity in male mice following joint injury

ABSTRACT: Osteoarthritis (OA) is a disease with sex-dependent prevalence and severity in both human and animal models. We sought to elucidate sex differences in synovitis, mechanical sensitization, structural damage, bone remodeling, and the synovial transcriptome in the anterior cruciate ligament rupture (ACLR) mouse model of post-traumatic OA (PTOA).

ORGANISM(S): Mus musculus

PROVIDER: GSE271903 | GEO | 2024/07/17

REPOSITORIES: GEO