Ddit4 deficiency leads to a defect in AE9a induced leukemia development
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ABSTRACT: Our research indicated knock out of DDIT4 markedly suppresses leukemia initiation potential, leukemia maintenance and self-renewal of AE9a leukemia cells in vivo. To better understand the molecular mechanisms underlying the role of DDIT4 in self-renewal of LSC and leukemia initiation, we performed global gene expression profiling by RNA sequencing on AE9a-Ddit4+/+ and AE9a-Ddit4-/- leukemia cells.
ORGANISM(S): Mus musculus
PROVIDER: GSE272010 | GEO | 2025/12/04
REPOSITORIES: GEO
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