ST2+ T-regulatory Cells in Renal Inflammation and Fibrosis following Ischemic Kidney Injury

ABSTRACT: The role of IL-33 and its receptor ST2 in kidney injury is not well understood. This study demonstrates the importance of ST2 expression on the T-regulatory cells (Tregs) for the resolution of renal injury by suppressing inflammation and fibrosis. Treg-specific deletion of ST2, detrimentally impacted late outcomes of renal injury worsening the impairment of kidney function, inflammation, and fibrosis.

ORGANISM(S): Mus musculus

PROVIDER: GSE272380 | GEO | 2024/08/27

REPOSITORIES: GEO