Podocyte-specific YAP activation triggers crescentic glomerulonephritis through cross-talk with parietal epithelial cells

ABSTRACT: YAP, a transcriptional co-activator, is known to control programs that are both cell- and context-dependent. We report that the overactivation of YAP (YAP5SA) in podocytes has both cell autonomous and non-cell autonomous consequences. RNA-seq analysis of YAP5SA-expressing compared to control podocytes revealed pathways and candidate genes that could explain both these effects.

ORGANISM(S): Homo sapiens

PROVIDER: GSE272779 | GEO | 2025/05/26

REPOSITORIES: GEO