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Determining the transcriptional regulation of CDK4/6 inhibitor resistance in estrogen receptor-positive breast cancer

ABSTRACT: CDK4/6 inhibitor (CDK4/6i) resistance is a pressing clinical problem for patients with ER+ breast cancer. Previous work identified CDK6 overexpression as one critical determinant of acquired resistance to CDK4/6 inhibition. This dataset interrogates CDK6 interactors/recruiters to determine their role in transcriptional regulation of CDK4/6i resistance mechanisms and will provide novel therapeutic strategies to overcome resistance.

ORGANISM(S): Homo sapiens

PROVIDER: GSE273133 | GEO | 2025/06/01

REPOSITORIES: GEO

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