FLI1 and GATA1 govern TLN1 transcription: new insights into FLI1-related platelet disorders

ABSTRACT: Germline variations in FLI1, essential for megakaryopoiesis, are linked to bleeding disorders, platelet aggregation defects and mild thrombocytopenia. However, the mechanisms behind these abnormalities remain unclear. This study aims to elucidate the impact of FLI1 variants on human megakaryocytes and platelets.

ORGANISM(S): Homo sapiens

PROVIDER: GSE273210 | GEO | 2025/03/31

REPOSITORIES: GEO