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Quiescent fibroblast-like synovial cells alleviate inflammatory bowel disease by modulating the gut immune microenvironment [dataset 1]

ABSTRACT: To explore the potential of stem cellsfromhuman exfoliated deciduous teeth (SHED) for the treatment of inflammatory bowel disease (IBD) by addressing their in vivo mechanisms.

ORGANISM(S): Homo sapiens

PROVIDER: GSE273276 | GEO | 2025/07/01

REPOSITORIES: GEO

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Quiescent fibroblast-like synovial cells alleviate inflammatory bowel disease by modulating the gut immune microenvironment [dataset2]

Project description:To explore the potential of stem cellsfromhuman exfoliated deciduous teeth (SHED) for the treatment of inflammatory bowel disease (IBD) by addressing their in vivo mechanisms.

2025-07-01 | GSE273277 | GEO

Gene Profiles of Mesenchymal Stromal Cells from Different Tissue

Project description:Mesenchymal stromal stem cells from human bone marrow (BMSCs), adipose tissuse (ADSCs) were purchased from ATCC. Human exfoliated deciduous dental pulps were cultured in vitro and purified to get stem cells from human exfoliated deciduous teeth (SHED). Markers of MSCs were checked before scRNA seq.

2023-09-12 | GSE157863 | GEO

SHED: control vs Hepatocyte-like cells

Project description:Profiling of chromosomal gains and losses in a genomic complement of stem cells from human exfoliated deciduous teeth comparing control undifferentieated SHED with hepatocyte differentiated SHED.

2018-02-01 | GSE102974 | GEO

Identification of gene related to stem cells from human exfoliated deciduous teeth (SHED) into epithelial-like differentiation using co-culture in epithelial microenvironment

Project description:We employed microarray profiling to determine the gene(s) that control human exfoliated deciduous teeth (SHED) differentiation into epithelial-like cells. We introduced epithelial microenvironment using keratinocyte serum free medium (KSFM) and co-culture with human epithelial keratinocyte (HEK001) to promote epithelial-like differentiation.

2024-02-01 | GSE165451 | GEO

Transcriptome analysis of bFGF and WNT3A treated stem cells isolated from human exfoliated deciduous teeth

Project description:bFGF regulated stemness maintenance and cell differentiation in stem cells isolated from human exfoliated deciduous teeth (SHEDs). In addition, WNT3A is also shown to regulate osteogenic differentiation in mesenchymal stem cells. Here, transcriptome analysis of bFGF and WNT3A treated SHEDs was evaluated using a high throughput RNA sequencing technique. Results demonstrated that bFGF regulated genes related to cell cycle control and cell proliferation in SHEDs.

2020-07-07 | GSE131758 | GEO

Inorganic Pyrophosphate influence Stem Cells from Human Exfoliated Deciduous Teeth

Project description:Inorganic Pyrophosphate influence Stem Cells from Human Exfoliated Deciduous Teeth

| PRJNA1185148 | ENA

Proteomics of exosomes derived from rat trigeminal ganglion neurons

Project description:Exosomes derived from rat trigeminal ganglion neurons (TGN) were harvested as control group. Exosomes derived from TGN after internalizing exosomes derived from stem cells from human exfoliated deciduous teeth (S-Exo) were harvested as treatment group.

2024-01-22 | PXD048746 |

Comparative gene expression analysis of the human dental pulp in deciduous and permanent teeth

Project description:Human deciduous and permanent teeth exhibit different developmental processes, morphologies, histological characteristics and life cycles. In addition their pulp tissues react differently to external stimuli, such as the pulp sensitivity test, dental trauma and pulp therapy materials. These differences are attributable to their genetic backgrounds. Therefore the purpose of this study is to compare the differences of dental pulp in deciduous and permanent teeth. Pulp samples were obtained from permanent premolars (n=6, aged 11-14 years) and deciduous teeth (n=6, aged 11-14 years). Comparative cDNA microarrary analysis revealed several differences in gene expression between the deciduous and permanent pulp tissues. Each GSM record represents a pulp sample pooled from two teeth samples.

2014-08-21 | E-GEOD-51449 | biostudies-arrayexpress

stem cells from human exfoliated deciduous teeth cultured with human platelet lysate

Project description:Stem cells from human exfoliated deciduous teeth (SHED) can be used as a potential clinical material. But the use of xenogeneic ingredients, especially fetal bovine serum, will increase the risk of zoonotic disease transmission during the use of animal-derived products. Human-platelet-lysate (hPL) was used in human cell expansion with reliability in clinical applications. This study aimed to explore the feasibility and effect of HPL in the cultivation of SHED. We use proteomics to interpret the impact of HPL on the protein profile of SHED. Propagation, differentiation, qPCR and immunofluorescence were used to detect the effect of HPL on SHED.

2022-05-19 | PXD026687 | Pride

Project description:RNA sequence in osteo/odontogenesis of stem cells from human exfoliated deciduous teeth

| PRJNA647828 | ENA