The potential impact of VHL on chromatin accessibility using the assay for ATAC-seq in Caki-1 cells.

ABSTRACT: To investigate the potential impact of VHL on chromatin accessibility, the assay for transposase-accessible chromatin with high throughput sequencing (ATAC-seq) was performed in renal cell carcinoma cells.The VHL wild-type Caki-1 cells were used to generate control or VHL knockout cells by CRISPR/Cas9-mediated genome editing (sgCTR and sgVHL Caki-1 cells).Following ATAC-seq, DNAs were amplified using non-biased conditions, labeled, and sequenced with Illumina NovaSeq 6000.

ORGANISM(S): Homo sapiens

PROVIDER: GSE273354 | GEO | 2026/01/23

REPOSITORIES: GEO