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RNA-seq of B7H3_CAR_T cells loaded with oncolytic virus VSVΔ51

ABSTRACT: Oncolytic viruses (OVs) have been evaluated as an additional method to increase the efficacy of chimeric antigen receptor (CAR)-T cells in treating solid tumors. Here, we designed a CAR moiety by inserting the CR2 and CR3 domains of low-density lipoprotein receptor, enabling specifically and significantly surface-loading of vesicular stomatitis virus (VSV) onto CAR-T cells. We used RNA sequence to study the global gene expression and identified differentially expressed genes in B7H3-CAR-T cells and CR2/3-B7H3-CAR-T cells loaded with loading VSVΔ51, aiming to identify the changed pathways that are influenced by the cross-connection between VSV-G protein and CR2/3-CAR moiety.

ORGANISM(S): Homo sapiens

PROVIDER: GSE273425 | GEO | 2025/07/31

REPOSITORIES: GEO

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