Vitamin C promotes epidermal proliferation by enhancing the DNA demethylation of proliferation-related genes in human epidermal equivalents (WGBS)

ABSTRACT: The stratified structure of the epidermis, the outermost layer of the skin, is highly regulated through the differentiation of keratinocytes. Vitamin C act as a cofactor for DNA demethylation enzyme ten-eleven translocation (TET) in epigenetic mechanism. Previous study revealed that VC deficiency causes epidermal atrophy in hairless mice unable to synthesize VC.

ORGANISM(S): Homo sapiens

PROVIDER: GSE273778 | GEO | 2025/04/09

REPOSITORIES: GEO