Genomics

Dataset Information

20

Disrupted processing of long pre-mRNAs and widespread RNA missplicing are components of neuronal vulnerability from loss of nuclear TDP-43


ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

INSTRUMENT(S): Illumina Genome Analyzer II (Mus musculus)

SUBMITTER: Gene Yeo  

PROVIDER: GSE27394 | GEO | 2011-03-03

SECONDARY ACCESSION(S): GSE27218 GSE27201PRJNA137005 GSE27371

REPOSITORIES: GEO

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Publications


We used cross-linking and immunoprecipitation coupled with high-throughput sequencing to identify binding sites in 6,304 genes as the brain RNA targets for TDP-43, an RNA binding protein that, when mutated, causes amyotrophic lateral sclerosis. Massively parallel sequencing and splicing-sensitive junction arrays revealed that levels of 601 mRNAs were changed (including Fus (Tls), progranulin and other transcripts encoding neurodegenerative disease-associated proteins) and 965 altered splicing ev  ...[more]

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