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Transcription factor networks disproportionately enrich for heritability of blood cell phenotypes [PRO-Seq]

ABSTRACT: We developed a strategy to couple highly-efficient pooled CRISPR-mediated perturbation of key master hematopoietic transcription factors in differentiating primary human hematopoietic cells with joint single-cell gene expression and chromatin accessibility profiling to enable the reconstruction of transcription factor-dependent gene regulatory networks throughout primary hematopoietic differentiation.

ORGANISM(S): Homo sapiens

PROVIDER: GSE274110 | GEO | 2025/04/03

REPOSITORIES: GEO

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