Transcriptomics

Dataset Information

24

MiRNA profiling from T-ALL cells


ABSTRACT: The NOTCH1 signaling pathway is a critical determinant of cell fate decisions and drives oncogenesis through mechanisms that are incompletely understood. To elucidate tumorigenic pathways that cooperate with activated Notch1 in leukemogenesis,we performed miRNA expression profiling of normal CD4+CD8+ thymocytes, non-malignant ICN1 over-expressing CD4+CD8+ cells and ICN1-induced tumor CD4+CD8+ cells. Overall design: Three groups of the murine T cells: Control CD4+CD8+ normal thymocytes vs.non-malignant ICN1-expressing CD4+CD8+ cells vs. ICN1-tumor CD4+CD8+ cells .

INSTRUMENT(S): Exiqon MicroRNA Array ver_208000 V8.1 lot number 20728-20399

ORGANISM(S): Mus musculus  

SUBMITTER: Xiaoyu Li  

PROVIDER: GSE27418 | GEO | 2011-02-19

SECONDARY ACCESSION(S): PRJNA137245

REPOSITORIES: GEO

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