Brain-wide neuronal circuit connectome of human glioblastoma

ABSTRACT: This study explores the circuit integration of human glioblastoma organoids (GBOs) in vivo in the adult mouse brain. We performed single cell RNA sequencing (scRNA-seq) to understand the cell state diversity of malignant tumor cells in GBOs at baseline and after stimulation by 1 mM acetylcholine (ACh) for 1 hour. Sliced neocortical organoids (SNOs) were also sequenced to study gene expression properties of neural stem cells (NSCs).

ORGANISM(S): Homo sapiens

PROVIDER: GSE274460 | GEO | 2024/12/20

REPOSITORIES: GEO