Genomics

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Transcriptomic Landscape of Fibroblasts Under IL-1β Stimulation [ATAC-seq]


ABSTRACT: In this study, we investigated the chromatin accessibility changes in human dermal fibroblasts in response to IL-1尾 stimulation, a key pro-inflammatory cytokine. Using ATAC-seq, we compared the open chromatin landscapes between control fibroblasts and those treated with IL-1尾. The data provide insights into the regulatory elements activated during fibroblast differentiation and their potential role in sustaining inflammation within the skin. These findings contribute to our understanding of fibroblast-mediated inflammation in autoimmune diseases like SLE and offer a resource for identifying novel therapeutic targets.

ORGANISM(S): Homo sapiens

PROVIDER: GSE274948 | GEO | 2025/08/07

REPOSITORIES: GEO

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