Single-Cell Sequencing Unveils Distal and Proximal Features of Induced Pluripotent Stem Cell-Derived Intestinal Organoids and cAMP’s role in enhancing multicellularity intestinal lineage specification.

ABSTRACT: This study aims to advance intestinal organoid models by characterizing mesenchyme-free regional-specific induced pluripotent stem cell (iPSC)-derived human intestinal organoids (HIOs) at single-cell resolution and investigating the impact of cyclic AMP (cAMP) on intestinal differentiation lineage specification.

ORGANISM(S): Homo sapiens

PROVIDER: GSE275068 | GEO | 2025/06/16

REPOSITORIES: GEO