Loss of an extensive ciliary connectome induces proteostasis and cell fate switching in a severe motile ciliopathy

ABSTRACT: CCDC39 is a motile cilia protein associated with primary ciliary dyskinesia. We used single cell RNA sequencing (scRNA-seq) to analyze the changes in cells types and gene expression profile of subjects with variants in CCDC39 compared to healthy individuals

ORGANISM(S): Homo sapiens

PROVIDER: GSE275070 | GEO | 2025/03/24

REPOSITORIES: GEO