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Shiga Toxin kidney

ABSTRACT: We performed single-cell transcriptome sequencing on control and shiga toxin induced kidneys to reveal kidney injury characteristics

ORGANISM(S): Mus musculus

PROVIDER: GSE275103 | GEO | 2026/01/01

REPOSITORIES: GEO

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Alterations in gene expression in response to different regimes of Shiga toxin 2

Project description:The microarray data provided here belong to a study that describes two different Shiga toxin (Stx) induced models of hemolytic uremic syndrome (HUS) in mice. Although several rodent models of HUS were published, it still remains difficult to reproduce all clinical features of human HUS. Here, two different Stx2 regimes combined with volume resuscitation were tested in C57BL/6J wild type mice. Animals were euthanized because of kidney injury after 3 or 7 days respectively. Kidneys were removed for histological evaluation and RNA extraction. Kidney injury was confirmed histologically and by laboratory parameters in plasma. Data for the respective vehicle treated groups are also provided here.

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