Effect of BCAT1 depletion on sensitivity to Etoposide in T-cell acute lymphoblastic leukemia cells

ABSTRACT: High levels of branched-chain amino acid (BCAA) transaminase 1 (Bcat1) have been associated with adverse prognosis and drug resistance in several cancer types. However, the mechanistic role of Bcat1 in T-cell acute lymphoblastic leukemia (T-ALL) development is ill defined.We determined the effects of BCAT1 depletion on cellular sensitivity to DNA damaging agents (etoposide).

ORGANISM(S): Homo sapiens

PROVIDER: GSE275161 | GEO | 2025/01/02

REPOSITORIES: GEO