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Expression data from diet-induced obesity Oma1-deficient mice.

ABSTRACT: Transriptional profiling of white adipose tissue extracted from obese mice.

ORGANISM(S): Mus musculus

PROVIDER: GSE27525 | GEO | 2012/01/01

SECONDARY ACCESSION(S): PRJNA137113

REPOSITORIES: GEO

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Expression data from diet-induced obesity Oma1-deficient mice.

Project description:Transriptional profiling of white adipose tissue extracted from obese mice. White adipose tissues were extrated from Oma1-deficient mouse and control after 20 weeks of diet-induced obesity. RNA were extracted and hybridated with Mouse Gene 1.0 ST from Affymetrix microarrays.

2012-01-01 | E-GEOD-27525 | biostudies-arrayexpress

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Project description:A hallmark of obesity is a pathological expansion of white adipose tissue that is accompanied by an increase in local inflammation and fibrosis. Autophagy is increased during obesity in adipose tissue, however, its role remains incompletely understood. Here, we report that autophagy is a critical regulator of pathological white adipose tissue remodelling and inflammation in diet-induced obese mice. The absence of adipocyte autophagy substantially exacerbates pericellular fibrosis specifically in gonadal white adipose tissue, ameliorating metabolic syndrome. Notably, changes in tissue architecture correlate with increased infiltration of macrophages and autophagy-dependent rewiring of adipocyte metabolism.

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Project description:Obesity is associated with an increased incidence of high grade prostate cancer (PC) and worse prognosis for PC patients. Recently, we showed in men that obesity-related periprostatic white adipose tissue (WAT) inflammation, characterized by macrophages surrounding dead or dying adipocytes forming crown-like structures, was associated with high grade PC. Possibly, interventions that suppress periprostatic WAT inflammation will improve outcomes for men with PC. Prior to testing interventions we conducted this study to identify transcriptomic differences in periprostatic fat from lean and obese mice. We hypothesized that periprostatic fat from obese mice would have a proinflammatory signature in gene expression pattern. To test our hypothesis that obese mice would develop molecular signatures of inflammation in periprostatic fat, we fed mice low fat diet or high fat diet for 12 weeks and then harvested periprostatic fat at sacrifice. RNA was isolated and analyzed from 5 lean and 5 obese mice and analyzed by microarray.

2019-07-22 | GSE123355 | GEO

Adipocyte autophagy-mediated signals in the control of macrophage phenotype during diet-induced obesity

Project description:A hallmark of obesity is a pathological expansion of white adipose tissue (WAT), accompanied by marked tissue dysfunction and fibrosis. Autophagy promotes adipocyte differentiation and lipid homeostasis, but its role in obese adipocytes and adipose tissue dysfunction remains incompletely understood. Using a mouse model, we demonstrate that autophagy is a key tissue-specific regulator of WAT remodelling in diet-induced obesity. Importantly, loss of adipocyte autophagy substantially exacerbates pericellular fibrosis in visceral WAT. Change in WAT architecture correlates with increased infiltration of macrophages with tissue-reparative, fibrotic features.

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Beneficial Metabolic Effects of Rapamycin are Associated with Enhanced Regulatory Cells in Diet-Induced Obese Mice.

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Analysis of obesity-induced DNA methylation in visceral adipose tissue

Project description:The purpose of this study was to use global gen expression to identify obesity-induced changes in gene expression profiles of lean and obese adolescent females. Visceral adipose tissue was extracted during abdominal surgeries on Lean and Obese adolescent females of african-americam, caucasian, and hispanic descent.

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Project description:We used microRNA microarrays to identify dysregulated microRNAs in macrophages isolated from adipose tissue of lean and obese mice.

2018-05-22 | GSE114736 | GEO

A Memory for Obesity in Adipose Tissue

Project description:To identify transcriptional alterations in subcutaneous human white adipose tissue of post-obese subjects, global gene expression measurements were performed. Three groups, obese before and after bariatric surgery as well as never-obese controls, were compared to dissect candidate genes.

2017-06-01 | GSE59034 | GEO

Transcriptional control of adipose tissue macrophages during high-fat diet-induced obesity.

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