Decreased estrogen level in ovariectomized mice causes an increase in oxidative stress in osteal macrophages leading to development of cellular senescence

ABSTRACT: Osteal macrophages were isolated from ovariectomized and control mice 4 weeks after surgery. Oeritoneal macrophages collected from ovariectomized mice exhibited gene signature of NADPH oxidase activation which is known as key modulator in aging and cell senescence.

ORGANISM(S): Mus musculus

PROVIDER: GSE275459 | GEO | 2024/11/26

REPOSITORIES: GEO