GeneQuery RNA Profile of Trigeminal Ganglia from Tumor Burden and Tumor Naïve Mice

ABSTRACT: Cancer patients often experience changes in mental health, prompting an exploration into whether nerves infiltrating tumors contribute to these alterations by impacting brain functions. Using a mouse model for head and neck cancer and neuronal tracing we show that tumor-infiltrating nerves connect to distinct brain areas. The activation of this neuronal circuitry altered behaviors (decreased nest-building, increased latency to eat a cookie, and reduced wheel running). Tumor-infiltrating nociceptor neurons exhibited heightened calcium activity and brain regions receiving these neural projections showed elevated Fos as well as increased calcium responses compared to non-tumor-bearing counterparts.

ORGANISM(S): Mus musculus Mus

PROVIDER: GSE275481 | GEO | 2024/08/30

REPOSITORIES: GEO